Appleby has played just once since signing from Kidderminster due to a knee injury. Recent surgery means that he could be out for around four months.
His former club Swansea are visitors to Boothferry Park tomorrow, and Jan Molby is expected to name an unchanged line-up.
Carl Regan (ankle), Shaun Smith (ribs) John Anderson (back) were doubts but are expected to play.
Welshman Mike Price is unlikely to be involved due to an ankle injury, while Lawrie Dudfield still isn't fit to start because of his troublesome knee.
Stuart Elliott may come into contention for the Reserves on Wednesday after returning to training from a knee injury, but will not be involved tomorrow.
Paul Musselwhite will continue in goal after keeping a clean sheet last week at Oxford.
Expected line-up (4-4-2): Musselwhite; Regan, Whittle, Anderson, Smith; Green, Ashbee, Keates, Williams; Alexander, Jevons.
Subs: Glennon, Edwards, Johnson, Dudfield, Bradshaw.