David Platt's side will come to Hull on Monday 2nd June to take on Serbia & Montenegro in a warm-up friendly for the European Championships qualifier against Slovakia a week later in Sunderland.
Platt said: "We are delighted to be playing at Hull's superb new stadium, and hope the local fans will turn up in force to see some top level international football."
City chairman and head of the Stadium Management Company Adam Pearson said he's "extremely proud" for Hull to be hosting an international fixture, and that the Football Association will reveal ticketing arrangements shortly.
There are already other top sporting events announced to take place at the KC Stadium, including Yorkshire v Rest of the World cricket in July and the second Ashes test between Great Britain and Australia rugby league in November, while a top act is being lined up for a concert on 19th July.