David Livermore and Stuart Elliott lose their places on the bench to Folan and Garcia.
Dean Windass makes his first 'Humber Derby' appearance alongside Fraizer Campbell up front, while Steve McPhee keeps his place on the wing.
Ex-Scunthorpe defender Andy Dawson remains on the bench, despite his goal in the 3-0 win over Preston.
City line-up: Boaz Myhill; Sam Ricketts, Michael Turner, Wayne Brown, Damien Delaney; Steve McPhee, Dean Marney, Ian Ashbee, Bryan Hughes; Dean Windass, Fraizer Campbell.
Subs from: Matt Duke, Andy Dawson, Richard Garcia, Jay-Jay Okocha, Caleb Folan.
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